AKR1C1
Sign in to saveAlso known as 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37
Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.
Gene data
AKR1C1- Name
- aldo-keto reductase family 1 member C1
- Type
- protein-coding
- Position
- 4,944,110–4,983,283 (+)
- Aliases
- 2-ALPHA-HSD, 20-ALPHA-HSD, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
- Ensembl
- ENSG00000187134
- RefSeq RNA
- NM_001353.6
- RefSeq protein
- NP_001344.2
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
aldo-keto reductase family 1 member C1
- Symbol
- AKR1C1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:4,944,110-4,983,283
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein AKR1C1 PDB 1ihi.png
Show 8 more facts
- HomoloGene ID
- 134114
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1645
- chromosome
- human chromosome 10
- genomic start
- 4934796
- genomic end
- 5025475
- cytogenetic location
- 10p15.1
- expressed in
- gallbladder
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Superfamily of enzymes
- Isozymes of aldo-keto reductase family 1 member C
- References
- See also
- External links
- Further reading
Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.
==Superfamily of enzymes== This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This specific enzyme, AKR1C1, among other reactions, catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. The AKR1C1 gene shares high sequence identity with three other gene members, and is clustered with those three genes at chromosome 10p15-p14.
Excerpted from Wikipedia’s “AKR1C1” article, available under the CC BY-SA 4.0 licence.