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GeneQ18032731· pop 5· linked from 12 articles

ALX1

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Also known as CART1, FND3, HEL23, ALX homeobox 1

ALX homeobox protein 1 is a protein that in humans is encoded by the ALX1 gene.

Gene data

ALX1

Name: ALX homeobox 1
Type: protein-coding
Position: 85,280,091–85,302,551 (+)
Aliases: CART1, FND3, HEL23
Ensembl: ENSG00000180318
RefSeq RNA: NM_006982.3
RefSeq protein: NP_008913.2

The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription positive regulation of epithelial to mesenchymal transition negative regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleoplasm transcription regulator complex nuclear body

via MyGene.info

Gene · Ensembl

ALX homeobox 1

Symbol: ALX1
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:85,280,091-85,302,551
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 5075
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/8092
genomic end: 85695562
genomic start: 85280220
chromosome: human chromosome 12
cytogenetic location: 12q21.31

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Function
Interactions
References
Further reading
External links

ALX homeobox protein 1 is a protein that in humans is encoded by the ALX1 gene.

== Function ==

Excerpted from Wikipedia’s “ALX1” article, available under the CC BY-SA 4.0 licence.

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