ARAP2
Sign in to saveAlso known as CENTD1, PARX, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.
Gene data
ARAP2- Name
- ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
- Type
- protein-coding
- Position
- 35,948,221–36,244,855 (−)
- Aliases
- CENTD1, PARX
- Ensembl
- ENSG00000047365
- RefSeq RNA
- NM_015230.4, NM_139182.1, NR_146893.2, NR_146894.2, XM_047449571.1
- RefSeq protein
- NP_056045.2, XP_047305527.1, XP_047305528.1, XP_047305529.1, XP_047305530.1
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
- Symbol
- ARAP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:35,948,221-36,244,855
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- References
- External links
- Further reading
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.
== Function ==
Excerpted from Wikipedia’s “ARAP2” article, available under the CC BY-SA 4.0 licence.