ARF5

Also known as ADP ribosylation factor 5

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

Gene data

ARF5

Name: ARF GTPase 5
Type: protein-coding
Position: 127,588,359–127,591,705 (+)
Ensembl: ENSG00000004059
RefSeq RNA: NM_001662.4
RefSeq protein: NP_001653.1

This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010].

Gene Ontology

Biological process

intracellular protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum vesicle-mediated transport positive regulation of TOR signaling lysosomal membrane organization

Molecular function

GTPase activity GTPase activity protein binding GTP binding GTP binding

Cellular component

cytoplasm cytoplasm lysosomal membrane lysosomal membrane Golgi apparatus Golgi apparatus plasma membrane plasma membrane

Pathways

Endocytosis - Homo sapiens (human)ER to Golgi Anterograde Transport Membrane Trafficking Metabolism of proteins Asparagine N-linked glycosylation Vesicle-mediated transport Post-translational protein modification COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi and retrograde Golgi-to-ER traffic

via MyGene.info

Gene · Ensembl

ARF GTPase 5

Symbol: ARF5
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:127,588,359-127,591,705
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: PDB 2b6h EBI.jpg

Show 8 more facts

exact match: identifiers.org/ncbigene/381
HomoloGene ID: 129625
found in taxon: Homo sapiens
genomic end: 127591700
genomic start: 127588386
chromosome: human chromosome 7
cytogenetic location: 7q32.1
expressed in: granulocyte

Sources (4)

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Encyclopedic overview

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ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

ADP-ribosylation factor 5 (ARF5) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF5 gene spans approximately 3.2kb of genomic DNA and contains six exons and five introns.

Excerpted from Wikipedia’s “ARF5” article, available under the CC BY-SA 4.0 licence.