ARFGAP3

Also known as ARFGAP1, ADP ribosylation factor GTPase activating protein 3

ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.

Gene data

ARFGAP3

Name: ARF GTPase activating protein 3
Type: protein-coding
Aliases: ARFGAP1

The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008].

via MyGene.info

Wikidata facts

Image: Protein ARFGAP3 PDB 2crw.png

Show 5 more facts

HomoloGene ID: 134103
exact match: identifiers.org/ncbigene/26286
genomic end: 43254112
genomic start: 43192508
cytogenetic location: 22q13.2

Sources (4)

via Wikidata · CC0

~1 min read

Article

3 sections

Contents

References
External links
Further reading

ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.

The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which is thought to interact with ADP-ribosylation factor 1 (ARF1). The encoded protein likely promotes hydrolysis of ARF1-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.