ARFGAP3
Sign in to saveAlso known as ARFGAP1, ADP ribosylation factor GTPase activating protein 3
ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.
Gene data
ARFGAP3- Name
- ARF GTPase activating protein 3
- Type
- protein-coding
- Position
- 42,796,502–42,858,106 (−)
- Aliases
- ARFGAP1
- Ensembl
- ENSG00000242247
- RefSeq RNA
- NM_001142293.2, NM_014570.5, XM_005261525.5, XM_054325525.1
- RefSeq protein
- NP_001135765.1, NP_055385.3, XP_005261582.1, XP_054181500.1
The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ARF GTPase activating protein 3
- Symbol
- ARFGAP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:42,796,502-42,858,106
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ARFGAP3 PDB 2crw.png
Show 7 more facts
- HomoloGene ID
- 134103
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/26286
- genomic end
- 43254112
- genomic start
- 43192508
- chromosome
- human chromosome 22
- cytogenetic location
- 22q13.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.
The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which is thought to interact with ADP-ribosylation factor 1 (ARF1). The encoded protein likely promotes hydrolysis of ARF1-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.
Excerpted from Wikipedia’s “ARFGAP3” article, available under the CC BY-SA 4.0 licence.