ARHGEF7
Sign in to saveAlso known as BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1
Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.
Gene data
ARHGEF7- Name
- Rho guanine nucleotide exchange factor 7
- Type
- protein-coding
- Position
- 111,114,559–111,305,737 (+)
- Aliases
- BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3
- Ensembl
- ENSG00000102606
- RefSeq RNA
- NM_001113511.2, NM_001113512.2, NM_001113513.2, NM_001320851.2, NM_001320852.1
- RefSeq protein
- NP_001106983.1, NP_001106984.1, NP_001106985.1, NP_001307780.1, NP_001307781.1
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
Rho guanine nucleotide exchange factor 7
- Symbol
- ARHGEF7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 13:111,114,559-111,305,737
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein ARHGEF7 PDB 1by1.png
Show 5 more facts
- HomoloGene ID
- 2895
- exact match
- identifiers.org/ncbigene/8874
- genomic end
- 111958084
- genomic start
- 111766906
- cytogenetic location
- 13q34
Sources (3)
via Wikidata · CC0
~4 min read
Article
6 sectionsContents
- Domains and functions
- Interactions
- See also
- References
- Further reading
- External links
Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.
ARHGEF7 is commonly known as the p21-activated protein kinase exchange factor beta (beta-PIX or βPIX), because it was identified by binding to p21-activated kinase (PAK) and also contains a guanine nucleotide exchange factor domain.