ASH1L
Sign in to saveAlso known as ASH1, ASH1L1, KMT2H, ASH1 like histone lysine methyltransferase, MRD52
ASH1L (also called huASH1, ASH1, ASH1L1, ASH1-like, or KMT2H) is a histone-lysine N-methyltransferase enzyme encoded by the ASH1L gene located at chromosomal band 1q22. ASH1L is the human homolog of Drosophila Ash1 (absent, small, or homeotic-like).
Gene data
ASH1L- Name
- ASH1 like histone lysine methyltransferase
- Type
- protein-coding
- Aliases
- ASH1, ASH1L1, KMT2H, MRD52
This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 10225
- exact match
- identifiers.org/ncbigene/55870
- genomic end
- 155563162
- genomic start
- 155305059
- cytogenetic location
- 1q22
via Wikidata · CC0
~6 min read
Article
8 sectionsContents
- Gene
- Structure
- Protein expression patterns and timing
- Function
- Role in human disease
- References
- Further reading
- External links
ASH1L (also called huASH1, ASH1, ASH1L1, ASH1-like, or KMT2H) is a histone-lysine N-methyltransferase enzyme encoded by the ASH1L gene located at chromosomal band 1q22. ASH1L is the human homolog of Drosophila Ash1 (absent, small, or homeotic-like).
== Gene == Ash1 was discovered as a gene causing an imaginal disc mutant phenotype in Drosophila. Ash1 is a member of the trithorax-group (trxG) of proteins, a group of transcriptional activators that are involved in regulating Hox gene expression and body segment identity. Drosophila Ash1 interacts with trithorax to regulate ultrabithorax expression.