ATF7IP

Also known as AM, ATF-IP, MCAF, MCAF1, p621, activating transcription factor 7 interacting protein

Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.

Gene data

ATF7IP

Name: activating transcription factor 7 interacting protein
Type: protein-coding
Position: 14,365,439–14,502,931 (+)
Aliases: AM, ATF-IP, ATF7IP1, MCAF, MCAF1, p621
Ensembl: ENSG00000171681
RefSeq RNA: NM_001286514.2, NM_001286515.2, NM_001388179.1, NM_001388180.1, NM_001388181.1
RefSeq protein: NP_001273443.1, NP_001273444.1, NP_001375108.1, NP_001375109.1, NP_001375110.1

ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010].

Gene Ontology

Biological process

DNA methylation-dependent constitutive heterochromatin formation regulation of DNA-templated transcription negative regulation of DNA-templated transcription positive regulation of DNA-templated transcription

Molecular function

transcription coregulator activity transcription coregulator activity transcription corepressor activity protein binding ATP hydrolysis activity

Cellular component

nucleus nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex

Pathways

Epigenetic regulation of gene expression Epigenetic regulation of gene expression PKMTs methylate histone lysines Chromatin modifying enzymes Chromatin organization Gene expression (Transcription)Gene expression (Transcription)Regulation of endogenous retroelements Regulation of endogenous retroelements Regulation of endogenous retroelements by KRAB-ZFP proteins

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Gene · Ensembl

activating transcription factor 7 interacting protein

Symbol: ATF7IP
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:14,365,439-14,502,931
Strand: Forward (+)
Assembly: GRCh38

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Wikidata facts

Instance of: gene

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HomoloGene ID: 10051
chromosome: human chromosome 12
cytogenetic location: 12p13.1
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/55729
genomic end: 14651697
genomic start: 14518610
expressed in: trigeminal ganglion

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Encyclopedic overview

4 sections

Contents

Interactions
References
Further reading
External links

Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.

==Interactions== ATF7IP has been shown to interact with MBD1. In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating T helper 17 cell (Th17) differentiation due to increased IL-2 production upon stimulation of the T cell receptor (TCR). This TCR stimulation occurs through deposition of H3K9me3, a repressive histone mark.

Excerpted from Wikipedia’s “ATF7IP” article, available under the CC BY-SA 4.0 licence.

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