AUP1

Name

AUP1 lipid droplet regulating VLDL assembly factor

Type

protein-coding

Position

74,526,636–74,529,966 (−)

Ensembl

ENSG00000115307

RefSeq RNA

NM_181575.5, NR_126510.2, NR_126511.2, XM_054342686.1

RefSeq protein

NP_853553.1, XP_054198661.1

The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].

via MyGene.info

Gene · Ensembl

AUP1 lipid droplet regulating VLDL assembly factor

Symbol

AUP1

Biotype

Protein coding

Organism

Homo sapiens

Location

2:74,526,636-74,529,966

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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