BAIAP2L1

Name

BAR/IMD domain containing adaptor protein 2 like 1

Type

protein-coding

Position

98,290,827–98,401,213 (−)

Aliases

IRTKS

Ensembl

ENSG00000006453

RefSeq RNA

NM_018842.5

RefSeq protein

NP_061330.2

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009].

via MyGene.info

Gene · Ensembl

BAR/IMD domain containing adaptor protein 2 like 1

Symbol

BAIAP2L1

Biotype

Protein coding

Organism

Homo sapiens

Location

7:98,290,827-98,401,213

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein BAIAP2L1 PDB 1spk.png

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