BCL2L10

Also known as BCL-B, Boo, Diva, bcl2-L-10, BCL2 like 10

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.

Gene data

BCL2L10

Name: BCL2 like 10
Type: protein-coding
Position: 52,109,263–52,112,775 (−)
Aliases: BCL-B, Boo, Diva, bcl2-L-10
Ensembl: ENSG00000137875
RefSeq RNA: NM_001306168.1, NM_020396.4
RefSeq protein: NP_001293097.1, NP_065129.1

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008].

Pathways

Apoptosis Modulation and Signaling Regulation of apoptosis by parathyroid hormone-related protein

via MyGene.info

Gene · Ensembl

BCL2 like 10

Symbol: BCL2L10
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:52,109,263-52,112,775
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 8396
exact match: identifiers.org/ncbigene/10017
genomic end: 52404972
genomic start: 52401460
cytogenetic location: 15q21.2

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Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus preventing caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.