BCL2L12
Sign in to saveAlso known as BCL2 like 12
Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.
Gene data
BCL2L12- Name
- BCL2 like 12
- Type
- protein-coding
- Position
- 49,664,622–49,673,917 (+)
- Ensembl
- ENSG00000126453
- RefSeq RNA
- NM_001040668.2, NM_001282516.2, NM_001282517.2, NM_001282519.2, NM_001282520.1
- RefSeq protein
- NP_001035758.2, NP_001269445.2, NP_001269446.2, NP_001269448.2, NP_001269449.1
This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
BCL2 like 12
- Symbol
- BCL2L12
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:49,664,622-49,673,917
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.
The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Excerpted from Wikipedia’s “BCL2L12” article, available under the CC BY-SA 4.0 licence.