BCL2L12
Sign in to saveAlso known as BCL2 like 12
Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.
Gene data
BCL2L12- Name
- BCL2 like 12
- Type
- protein-coding
This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
via MyGene.info
Gene · Ensembl
BCL2 like 12
- Symbol
- BCL2L12
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:49,664,622-49,673,917
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 12619
- exact match
- identifiers.org/ncbigene/83596
- genomic end
- 50177173
- genomic start
- 50168823
- cytogenetic location
- 19q13.33
Sources (4)
via Wikidata · CC0
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- Further reading
Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.
The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.