Structure via PubChem · Public domain (PubChem)
bisacodyl
Sign in to saveAlso known as 4,4'-(2-pyridinylmethylene)bisphenol diacetate ester
Bisacodyl is an organic compound that is used as a stimulant laxative drug. It works directly on the colon to produce a bowel movement. It is typically prescribed for relief of episodic and chronic constipation and for the management of neurogenic bowel dysfunction, as well as part of bowel preparation before medical examinations, such as for a colonoscopy.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 414908012
- Drug.IUPAC_name
- (pyridin-2-ylmethanediyl)dibenzene-4,1-diyl diacetate OR 4,4'-(pyridin-2-ylmethylene)bis(4,1-phenylene) diacetate
- Drug.image
- Bisacodyl skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Bisacodyl-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Fleet, Dulcolax, Brooklax, others
- Drug.MedlinePlus
- a601027
- Drug.DailyMedID
- Bisacodyl
- Drug.routes_of_administration
- By mouth, rectal
- Drug.ATC_prefix
- A06
- Drug.ATC_suffix
- AB02
- Drug.legal_AU
- S2
- Drug.legal_US
- OTC
- Drug.legal_US_comment
- / Rx-only
- Drug.legal_status
- OTC
via Wikipedia infobox
Chemical data
- Formula
- C22H19NO4
- Molecular weight
- 361.4 g/mol
- IUPAC name
- [4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate
- SMILES
- CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(=O)C)C3=CC=CC=N3
- InChIKey
- KHOITXIGCFIULA-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 65.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
777 papers- Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation.Neurogastroenterology and motility · 2021
- [Bisacodyl as laxative in Belgian pharmacy].Journal de pharmacie de Belgique · 2016
- Bisacodyl Limits Chikungunya Virus Replication In Vitro and Is Broadly Antiviral.Antimicrobial agents and chemotherapy · 2022
- Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review.The American journal of gastroenterology · 2021
- Bisacodyl Suppresses TGF-α-Induced MUC5AC Production in NCI-H292 Cells.Biological & pharmaceutical bulletin · 2021
via PubMed
Wikidata facts
- Mass
- 361.131408
Show 4 more facts
- chemical formula
- C₂₂H₁₉NO₄
- Commons category
- Bisacodyl
- canonical SMILES
- CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(=O)C)C3=CC=CC=N3
- defined daily dose
- 10
Sources (6)
via Wikidata · CC0
~2 min read
Article
5 sectionsContents
- Medical uses
- Available forms
- Administration
- Mechanism of action
- References
Bisacodyl is an organic compound that is used as a stimulant laxative drug. It works directly on the colon to produce a bowel movement. It is typically prescribed for relief of episodic and chronic constipation and for the management of neurogenic bowel dysfunction, as well as part of bowel preparation before medical examinations, such as for a colonoscopy.
Bisacodyl is a derivative of triphenylmethane. It was first used as a laxative in 1953 because of its structural similarity to phenolphthalein.