BUB1

Name

BUB1 mitotic checkpoint serine/threonine kinase

Type

protein-coding

Position

110,635,468–110,678,098 (−)

Aliases

BUB1A, BUB1L, MCPH30, hBUB1

Ensembl

ENSG00000169679

RefSeq RNA

NM_001278616.2, NM_001278617.2, NM_004336.5, XM_047445616.1, XM_054343580.1

RefSeq protein

NP_001265545.1, NP_001265546.1, NP_004327.1, XP_047301572.1, XP_054199555.1

This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

via MyGene.info

Gene · Ensembl

BUB1 mitotic checkpoint serine/threonine kinase

Symbol

BUB1

Biotype

Protein coding

Organism

Homo sapiens

Location

2:110,635,468-110,678,098

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

BUB1 3E7E.png

via Wikidata · CC0