C-reactive protein
Sign in to saveAlso known as C-reactive protein, pentraxin-related, uniprot:P02741, CRP, pentraxin 1
annular pentameric protein found in blood plasma whose circulating concentrations rise in response to inflammation
OverviewAI-generated
C-reactive protein is a human protein encoded by the CRP gene. The molecule has a length of 224 amino acids and a mass of 25039. It is associated with calcium and acute phase responses, and its structure has been determined through three-dimensional analysis and direct protein sequencing. The protein exists at the protein level, and its entry in the UniProt database is reviewed.
Research interest in this compound is substantial, with 124,268 entries in PubMed and 389 listings in ClinicalTrials.gov. The subject is also referenced by 435 other encyclopedia articles.
Synthesized by Vinony from 16 facts across 5 sources: Wikidata, PubMed, ClinicalTrials.gov, UniProt, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Pdb
- Ortholog search: PDBe RCSB
via Wikipedia infobox
Protein · UniProt
C-reactive protein
- Gene
- CRP
- Organism
- Homo sapiens (Human)
- Length
- 224 aa
- Molecular mass
- 25,039 Da
- Evidence
- 1: Evidence at protein level
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells
Swiss-Prot (reviewed) · via UniProt
Research
124,268 papers- C-reactive protein: a critical update.The Journal of clinical investigation · 2003
- Editorial: Biology of C-reactive protein.Frontiers in immunology · 2024
- Immunoanalytical characteristics of C-reactive protein and high sensitivity C-reactive protein.Annales de biologie clinique · 2017
- Regulation of C-reactive protein conformation in inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019
- C-reactive protein reassessed.The New England journal of medicine · 2004
via PubMed
Clinical Trials
389 registered- UNKNOWNEvaluation of Endocrine and Metabolic Parameters in the New Diagnostic Phenotypes of Polycystic Ovary SyndromeUniversidad Nacional de Córdoba · NCT00784615
- COMPLETEDAssociation Between Inflammatory Biomarkers in CVD Patients on Empagliflozin.Damanhour University · NCT05911724
- NACOMPLETEDThe Effects of a Jump Rope Exercise Program on Vascular Health, Inflammatory Markers in Prehypertensive Adolescent GirlsPusan National University · NCT03534427
- RECRUITINGThe Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)University of Michigan · NCT04855396
- UNKNOWNDiagnostic Values of C-reactive Protein and Procalcitonin in Predicting Bacterial Infection in Acute Exacerbations of Chronic Obstructive Pulmonary DiseaseAssiut University · NCT03923803
- NACOMPLETEDInflammatory Stress Response in Pediatric Inguinal Hernia RepairUniversity Hospital of Split · NCT03203343
~17 min read
Encyclopedic overview
Identifiers AliasesCRP, PTX1, C-reactive protein, pentraxin-related, C-Reactive Protein External IDsOMIM: 123260; MGI: 88512; HomoloGene: 128039; GeneCards: CRP; OMA:CRP - orthologs
More reference expression data
Excerpted from Wikipedia’s “C-reactive protein” article, available under the CC BY-SA 4.0 licence.