C6orf58
Sign in to saveAlso known as LEG1, chromosome 6 open reading frame 58
C6orf58 is a human gene located at locus 6q22.33 of chromosome 6 and encodes for UPF0762, a protein which is subsequently secreted after cleavage of a signal peptide. DUF781, which is the singular identifiable domain in UPF0762, is tied to liver development in an orthologous protein in zebrafish. The function of the human UPF0762 is not yet well characterized.
Gene data
C6orf58- Name
- chromosome 6 open reading frame 58
- Type
- protein-coding
- Aliases
- LEG1
Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
chromosome 6 open reading frame 58
- Symbol
- C6orf58
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:127,519,455-127,591,820
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 134042
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/352999
- genomic end
- 127591820
- genomic start
- 127840600
- chromosome
- human chromosome 6
- cytogenetic location
- 6q22.33
- Commons category
- C6orf58
Sources (4)
via Wikidata · CC0
~6 min read
Encyclopedic overview
13 sectionsContents
- Gene and mRNA
- Expression
- Gene Neighborhood
- Homology
- Protein
- Properties
- Homology
- Conserved domains
- Post-translational modifications
- Interactions
- Pathology
- References
- External links
C6orf58 is a human gene located at locus 6q22.33 of chromosome 6 and encodes for UPF0762, a protein which is subsequently secreted after cleavage of a signal peptide. DUF781, which is the singular identifiable domain in UPF0762, is tied to liver development in an orthologous protein in zebrafish. The function of the human UPF0762 is not yet well characterized.
==Gene and mRNA== {| class="wikitable" |- ! Genomic DNA Length (base pairs) !! Exons !! Mature mRNA Length (base pairs) !! Splice variants !! Signal peptide CDS (base pair) !! Mature Peptide CDS (base pair) !! 5'-UTR (base pair) !! 3'-UTR (base pair) |- | 14644 || 6 || 1200 || 3 || 13-72 || 73-1002 || 1-12 || 1003-1200 |}
Excerpted from Wikipedia’s “C6orf58” article, available under the CC BY-SA 4.0 licence.