CABYR

Also known as CABYRa, CABYRc, CABYRc/d, CABYRe, CBP86, CT88, FSP-2, FSP2

Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYR gene.

Gene data

CABYR

Name: calcium binding tyrosine phosphorylation regulated
Type: protein-coding
Position: 24,138,987–24,161,603 (+)
Aliases: CABYRa, CABYRc, CABYRc/d, CABYRe, CBP86, CT88, FSP-2, FSP2
Ensembl: ENSG00000154040
RefSeq RNA: NM_001308231.2, NM_012189.4, NM_138643.3, NM_138644.3, NM_153768.3
RefSeq protein: NP_001295160.1, NP_036321.2, NP_619584.1, NP_619585.1, NP_722452.1

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013].

Gene Ontology

Biological process

epithelial cilium movement involved in extracellular fluid movement sperm capacitation sperm capacitation

Molecular function

calcium ion binding calcium ion binding calcium ion binding protein binding SH3 domain binding enzyme binding protein domain specific binding

Cellular component

extracellular region nucleus nucleus nucleoplasm cytoplasm cytoplasm cytoplasm cytosol

via MyGene.info

Wikidata facts

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HomoloGene ID: 49299
exact match: identifiers.org/ncbigene/26256
genomic end: 24161600
genomic start: 24138987
cytogenetic location: 18q11.2

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Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYR gene.

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized.