CAD

Name

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Type

protein-coding

Position

27,217,345–27,245,683 (+)

Aliases

CDG1Z, DEE50, EIEE50, GATD4

Ensembl

ENSG00000084774

RefSeq RNA

NM_001306079.2, NM_001445584.1, NM_001445585.1, NM_001445586.1, NM_001445587.1

RefSeq protein

NP_001293008.1, NP_001432513.1, NP_001432514.1, NP_001432515.1, NP_001432516.1

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].

via MyGene.info

Gene · Ensembl

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Symbol

CAD

Biotype

Protein coding

Organism

Homo sapiens

Location

2:27,217,345-27,245,683

Strand

Forward (+)

Assembly

GRCh38