CARD14

Also known as BIMP2, CARMA2, PRP, PSORS2, PSS1, caspase recruitment domain family member 14

Caspase recruitment domain-containing protein 14, also known as D-containing MAGUK protein 2 (Carma 2), is a protein in the CARD-CC protein family that in humans is encoded by the CARD14 gene.

In the Vinony graph

Within Vinony's link graph, CARD14 is referenced by 11 other articles, and connects out to psoriasis, Q180686 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 17.

Its subject is documented across 6 Wikipedia language editions.

Gene data

CARD14

Name: caspase recruitment domain family member 14
Type: protein-coding
Position: 80,169,992–80,216,073 (+)
Aliases: BIMP2, CARMA2, PRP, PSORS2, PSS1
Ensembl: ENSG00000141527
RefSeq RNA: NM_001257970.1, NM_001366385.1, NM_024110.4, NM_052819.3, NR_047566.2
RefSeq protein: NP_001244899.1, NP_001353314.1, NP_077015.2, NP_438170.1, XP_011523515.1

This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012].

Gene Ontology

Biological process

positive regulation of protein phosphorylation signal transduction activation of NF-kappaB-inducing kinase activity tumor necrosis factor-mediated signaling pathway regulation of apoptotic process negative regulation of apoptotic process regulation of canonical NF-kappaB signal transduction positive regulation of canonical NF-kappaB signal transduction

Molecular function

protein binding signaling adaptor activity CARD domain binding

Cellular component

cytoplasm cytoplasm cytoplasm cytosol plasma membrane CBM complex

Pathways

NF-kappa B signaling pathway - Homo sapiens (human)Apoptosis-related network due to altered Notch3 in ovarian cancer

via MyGene.info

Gene · Ensembl

caspase recruitment domain family member 14

Symbol: CARD14
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:80,169,992-80,216,073
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 11469
exact match: identifiers.org/ncbigene/79092
genomic end: 78183130
genomic start: 78143791
cytogenetic location: 17q25.3

Sources (4)

via Wikidata · CC0

~3 min read

Encyclopedic overview

6 sections

Contents

Structure
Function
Link to psoriasis
References
Further reading
External links

Caspase recruitment domain-containing protein 14, also known as D-containing MAGUK protein 2 (Carma 2), is a protein in the CARD-CC protein family that in humans is encoded by the CARD14 gene.

== Structure ==

Excerpted from Wikipedia’s “CARD14” article, available under the CC BY-SA 4.0 licence.