CARF

Also known as ALS2CR8, NYD-SP24, calcium responsive transcription factor

Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein also known as calcium-response factor (CaRF) is a protein that in humans is encoded by the ALS2CR8 gene.

Gene data

CARF

Name: calcium responsive transcription factor
Type: protein-coding
Position: 202,912,214–202,988,263 (+)
Aliases: ALS2CR8, NYD-SP24
Ensembl: ENSG00000138380
RefSeq RNA: NM_001104586.4, NM_001282910.3, NM_001282911.3, NM_001282912.3, NM_001322427.3
RefSeq protein: NP_001098056.1, NP_001269839.1, NP_001269840.1, NP_001269841.1, NP_001309356.1

Enables DNA binding activity and DNA-binding transcription factor activity. Involved in cellular response to potassium ion and positive regulation of transcription from RNA polymerase II promoter in response to calcium ion. Predicted to be located in granular component. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II cellular response to calcium ion

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding

Cellular component

nucleus nucleus nucleus

via MyGene.info

Gene · Ensembl

calcium responsive transcription factor

Symbol: CARF
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:202,912,214-202,988,263
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 11689
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/79800
genomic end: 202988263
genomic start: 203776937
expressed in: popliteal artery
chromosome: human chromosome 2
cytogenetic location: 2q33.2

Sources (3)

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Encyclopedic overview

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Contents

References
External links
Further reading

Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein also known as calcium-response factor (CaRF) is a protein that in humans is encoded by the ALS2CR8 gene.

Knocking out the Carf (Als2cr8) gene in mice results in learning associated deficits. Furthermore, Carf has been shown to function as a transcription factor that regulates the expression of BDNF.

Excerpted from Wikipedia’s “CARF” article, available under the CC BY-SA 4.0 licence.

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What links here1 pages

human chromosome 2

Entity