CASP8AP2
Sign in to saveAlso known as CED-4, FLASH, RIP25, caspase 8 associated protein 2
CASP8-associated protein 2 is a protein, that in humans is encoded by the CASP8AP2 gene.
Gene data
CASP8AP2- Name
- caspase 8 associated protein 2
- Type
- protein-coding
- Position
- 89,829,894–89,874,436 (+)
- Aliases
- CED-4, FLASH, RIP25
- Ensembl
- ENSG00000288475
- RefSeq RNA
- NM_001137667.2, NM_001137668.2, NM_012115.4, XM_054332061.1, XM_054332062.1
- RefSeq protein
- NP_001131139.1, NP_001131140.1, NP_036247.1, XP_054188036.1, XP_054188037.1
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 8066
- exact match
- identifiers.org/ncbigene/9994
- genomic end
- 89874436
- genomic start
- 89829894
- cytogenetic location
- 6q15
Sources (4)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
CASP8-associated protein 2 is a protein, that in humans is encoded by the CASP8AP2 gene.
== Function ==