CAVIN2
Sign in to saveAlso known as PS-p68, SDR, cavin-2, SDPR, serum deprivation response, caveolae associated protein 2
Cavin-2 or Serum deprivation-response protein (SDPR) is a protein that in humans is encoded by the SDPR gene. Cavin-2 is highly expressed in a variety of human endothelial cells.
Gene data
CAVIN2- Name
- caveolae associated protein 2
- Type
- protein-coding
- Position
- 191,834,298–191,847,253 (−)
- Aliases
- PS-p68, SDPR, SDR, cavin-2
- Ensembl
- ENSG00000168497
- RefSeq RNA
- NM_004657.6
- RefSeq protein
- NP_004648.1
This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
caveolae associated protein 2
- Symbol
- CAVIN2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:191,834,298-191,847,253
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 3422
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8436
- genomic end
- 191847088
- genomic start
- 191834310
- chromosome
- human chromosome 2
- cytogenetic location
- 2q32.3
- expressed in
- pericardium
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Function
- Secretion
- Clinical significance
- References
- Further reading
Cavin-2 or Serum deprivation-response protein (SDPR) is a protein that in humans is encoded by the SDPR gene. Cavin-2 is highly expressed in a variety of human endothelial cells.
This gene has a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein has also been shown to be a substrate for protein kinase C (PKC) phosphorylation.
Excerpted from Wikipedia’s “CAVIN2” article, available under the CC BY-SA 4.0 licence.