CCNF

Name

cyclin F

Type

protein-coding

Position

2,429,394–2,458,913 (+)

Aliases

FBX1, FBXO1, FTDALS5

Ensembl

ENSG00000162063

RefSeq RNA

NM_001323538.2, NM_001761.3

RefSeq protein

NP_001310467.1, NP_001752.2

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

cyclin F

Symbol

CCNF

Biotype

Protein coding

Organism

Homo sapiens

Location

16:2,429,394-2,458,913

Strand

Forward (+)

Assembly

GRCh38