CDON

Also known as CDO, CDON1, HPE11, ORCAM, cell adhesion associated, oncogene regulated, Ihog

Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene.

Gene data

CDON

Name: cell adhesion associated, oncogene regulated
Type: protein-coding
Position: 125,955,796–126,063,335 (−)
Aliases: CDO, CDON1, HPE11, Ihog, ORCAM
Ensembl: ENSG00000064309
RefSeq RNA: NM_001243597.3, NM_001378964.1, NM_001441161.1, NM_001441162.1, NM_001441163.1
RefSeq protein: NP_001230526.1, NP_001365893.1, NP_001428090.1, NP_001428091.1, NP_001428092.1

This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011].

Gene Ontology

Biological process

cell adhesion smoothened signaling pathway smoothened signaling pathway nervous system development positive regulation of smoothened signaling pathway positive regulation of smoothened signaling pathway negative regulation of biomineral tissue development negative regulation of biomineral tissue development

Molecular function

protein binding coreceptor activity protein carrier activity protein carrier activity

Cellular component

plasma membrane plasma membrane plasma membrane protein-containing complex

Pathways

Hedgehog signaling pathway - Homo sapiens (human)Developmental Biology Developmental Biology Signal Transduction Myogenesis Myogenesis Signaling by Hedgehog Ligand-receptor interactions Hedgehog 'on' state Activation of SMO

via MyGene.info

Gene · Ensembl

cell adhesion associated, oncogene regulated

Symbol: CDON
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:125,955,796-126,063,335
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein CDON PDB 3D1M.png

Show 7 more facts

HomoloGene ID: 22996
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/50937
genomic end: 125933230
genomic start: 125825691
chromosome: human chromosome 11
cytogenetic location: 11q24.2

Sources (4)

via Wikidata · CC0

~3 min read

Encyclopedic overview

7 sections

Contents

Structure and function
Clinical significance
Gene knockdown studies
Interactions
References
Further reading
External links

Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene.

CDON and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.

Excerpted from Wikipedia’s “CDON” article, available under the CC BY-SA 4.0 licence.