Cereblon
Sign in to saveAlso known as protein cereblon, protein x 0001, CRBN
Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans.
Protein · UniProt
Protein cereblon
- Gene
- CRBN
- Organism
- Homo sapiens (Human)
- Length
- 442 aa
- Molecular mass
- 50,546 Da
- Evidence
- 1: Evidence at protein level
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2 or GLUL (PubMed:26990986, PubMed:33009960). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (PubMed:20223979, PubMed:24328678, PubMed:25043012, PubMed:25108355). Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance …
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
8 registered- UNKNOWNIncidence of Cereblon in Intensive Care PatientsBuca Seyfi Demirsoy State Hospital · NCT05083520
- PHASE1TERMINATEDA Dose-finding Study of CC-90009 in Subjects With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher-risk Myelodysplastic SyndromesCelgene · NCT02848001
- PHASE1/PHASE2WITHDRAWNGolcadomide and Nivolumab in Patients With Non-Hodgkin Lymphoma With Refractory Disease After Chimeric Antigen T-cell TherapyUniversity of Pittsburgh · NCT06767956
- PHASE1/PHASE2WITHDRAWNMezigdomide Plus Ixazomib and Dexamethasone for Relapsed and Refractory Multiple MyelomaKathleen Dorritie · NCT06050512
- PHASE1RECRUITINGStudy of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple MyelomaAbbVie · NCT06896916
- PHASE3ACTIVE_NOT_RECRUITINGOpen-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)Celgene · NCT04975997
~3 min read
Encyclopedic overview
10 sectionsContents
- Function
- Ubiquitination and role in development
- Regulation of potassium channels
- Clinical significance
- Birth defects
- Intellectual disability
- Targeted protein degradation
- References
- Further reading
- External links
Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans.
== Function ==
Excerpted from Wikipedia’s “Cereblon” article, available under the CC BY-SA 4.0 licence.