CGB1
Sign in to saveAlso known as chorionic gonadotropin beta subunit 1, chorionic gonadotropin subunit beta 1
Choriogonadotropin subunit beta variant 1 is a protein that in humans is encoded by the CGB1 gene.
Gene data
CGB1- Name
- chorionic gonadotropin subunit beta 1
- Type
- protein-coding
- Position
- 49,035,569–49,036,895 (−)
- Ensembl
- ENSG00000267631
- RefSeq RNA
- NM_001382421.1, NM_033377.2
- RefSeq protein
- NP_001369350.1, NP_203695.2
The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Cellular component
via MyGene.info
Gene · Ensembl
chorionic gonadotropin subunit beta 1
- Symbol
- CGB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:49,035,569-49,036,895
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- PBB Protein CGB image.jpg
Show 6 more facts
- HomoloGene ID
- 137643
- exact match
- identifiers.org/ncbigene/114335
- genomic start
- 49035569
- genomic end
- 49552400
- cytogenetic location
- 19q13.33
- Commons category
- CGB1
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- References
- Further reading
- External links
Choriogonadotropin subunit beta variant 1 is a protein that in humans is encoded by the CGB1 gene.
The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranslated region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.