CHKB

Also known as CHETK, CHKL, CK, CKB, CKEKB, EK, EKB, MDCMC

protein-coding gene in the species Homo sapiens

Gene data

CHKB

Name: choline kinase beta
Type: protein-coding
Position: 50,578,959–50,601,455 (−)
Aliases: CHETK, CHKL, CK, CKB, CKEKB, EK, EKB, MDCMC
Ensembl: ENSG00000100288
RefSeq RNA: NM_005198.5, NM_152253.1
RefSeq protein: NP_005189.2

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009].