chondroblast
Sign in to saveChondroblasts, or perichondrial cells, is the name given to mesenchymal progenitor cells in situ which, from endochondral ossification, will form chondrocytes in the growing cartilage matrix. Another name for them is subchondral cortico-spongious progenitors. They have euchromatic nuclei and stain by basic dyes.
Key facts
- Cell.Name
- Chondroblast
- Cell.Latin
- chondroblastus
- Cell.Image
- Diagram of cartilage cells called chondroblasts CRUK 032.svg
- Cell.Caption
- Diagram of chondroblasts
via Wikipedia infobox
Wikidata facts
Show 2 more facts
- native label
- chondroblastus
- Commons category
- Chondroblasts
Sources (1)
via Wikidata · CC0
~8 min read
Article
12 sectionsContents
- Structure
- Matrix formation and composition
- Development
- Signaling, transcription and environmental factors responsible for chondroblast creation
- Transcription factors
- Wnt/β-catenin signaling
- Retinoic acid
- Environmental factors
- Function
- Pathology
- See also
- References
Chondroblasts, or perichondrial cells, is the name given to mesenchymal progenitor cells in situ which, from endochondral ossification, will form chondrocytes in the growing cartilage matrix. Another name for them is subchondral cortico-spongious progenitors. They have euchromatic nuclei and stain by basic dyes.
These cells are extremely important in chondrogenesis due to their role in forming both the chondrocytes and cartilage matrix which will eventually form cartilage. Use of the term is technically inaccurate since mesenchymal progenitors can also technically differentiate into osteoblasts or fat. Chondroblasts are called chondrocytes when they embed themselves in the cartilage matrix, consisting of proteoglycan and collagen fibers, until they lie in the matrix lacunae. Once they embed themselves into the cartilage matrix, they grow the cartilage matrix by growing more cartilage extracellular matrix rather than by dividing further.