CLDN4

Also known as CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R, claudin 4

Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins.

Gene data

CLDN4

Name: claudin 4
Type: protein-coding
Position: 73,799,542–73,832,690 (+)
Aliases: CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R
Ensembl: ENSG00000189143
RefSeq RNA: NM_001305.5
RefSeq protein: NP_001296.1

The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013].

Pathways

Cell adhesion molecules - Homo sapiens (human)Tight junction - Homo sapiens (human)Leukocyte transendothelial migration - Homo sapiens (human)Pathogenic Escherichia coli infection - Homo sapiens (human)Hepatitis C - Homo sapiens (human)Cell-Cell communication Tight junction interactions Cell-cell junction organization Cell junction organization Mammary gland development pathway - Embryonic development (Stage 1 of 4)

via MyGene.info

Gene · Ensembl

claudin 4

Symbol: CLDN4
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:73,799,542-73,832,690
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 1000
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1364
chromosome: human chromosome 7
genomic start: 73213872
genomic end: 73832690
cytogenetic location: 7q11.23

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

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References
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Further reading

Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins.

This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

Excerpted from Wikipedia’s “CLDN4” article, available under the CC BY-SA 4.0 licence.