CLEC1B

Also known as 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B

C-type lectin domain family 1 member B (also termed CLEC-1b, C-type lectin-like receptor 2, CLEC-2, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B, CLEC1B, activation-induced C-type lectin, AICL, and 1810061I13Rik) is a cell surface receptor protein. It binds certain biomolecules that act as ligands that when bound to the CLEC-1b expressed by cells stimulates certain functions in these cells. The human CLEC-1b receptor is encoded by the CLEC1B gene which is located on the short (i.e., "p")-arm of chromosome 12 at region 1, band 3, sub-band 1 to sub-band 2 (position not

Gene data

CLEC1B

Name: C-type lectin domain family 1 member B
Type: protein-coding
Position: 9,985,642–10,013,424 (−)
Aliases: 1810061I13Rik, CLEC2, PRO1384, QDED721
Ensembl: ENSG00000165682
RefSeq RNA: NM_001099431.2, NM_001393342.1, NM_016509.4, XM_011520685.3, XM_047428938.1
RefSeq protein: NP_001092901.1, NP_001380271.1, NP_057593.3, XP_011518987.1, XP_047284894.1

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011].