CLPTM1L
Sign in to saveAlso known as CRR9, CLPTM1-like, CLPTM1 like
Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene. CRR9p is associated with cisplatin-induced apoptosis. CLPTM1L, which lies within a cancer susceptibility locus on chromosome 5 (5p15.33), has been found to be commonly over-expressed in lung tumors and to confer resistance to apoptosis caused by genotoxic agents in association with up-regulation of the anti-apoptotic protein, Bcl-xL. Inhibition of CLPTM1L has been shown to inhibit oncogenic tra
Gene data
CLPTM1L- Name
- CLPTM1 like
- Type
- protein-coding
- Position
- 1,316,821–1,345,100 (−)
- Aliases
- CRR9
- Ensembl
- ENSG00000274811
- RefSeq RNA
- NM_030782.5, XM_011514144.3, XM_024446222.2, XM_054353568.1, XM_054353569.1
- RefSeq protein
- NP_110409.2, XP_011512446.1, XP_024301990.1, XP_054209543.1, XP_054209544.1
The protein encoded by this gene is a membrane protein whose overexpression in cisplatin-sensitive cells causes apoptosis. Polymorphisms in this gene have been reported to increase susceptibility to several cancers, including lung, pancreatic, and breast cancers. [provided by RefSeq, Nov 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
CLPTM1 like
- Symbol
- CLPTM1L
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:1,316,821-1,345,100
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 12767
- genetic association
- lung cancer
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/81037
- chromosome
- human chromosome 5
- genomic start
- 1317752
- genomic end
- 1345214
- cytogenetic location
- 5p15.33
- expressed in
- body of stomach
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- External links
- Further reading
Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene. CRR9p is associated with cisplatin-induced apoptosis. CLPTM1L, which lies within a cancer susceptibility locus on chromosome 5 (5p15.33), has been found to be commonly over-expressed in lung tumors and to confer resistance to apoptosis caused by genotoxic agents in association with up-regulation of the anti-apoptotic protein, Bcl-xL. Inhibition of CLPTM1L has been shown to inhibit oncogenic transformation and tumorigenesis caused by the KRas oncogene partially through the PI3K/Akt survival signaling axis.
== See also == Cleft lip and palate transmembrane protein 1
Excerpted from Wikipedia’s “CLPTM1L” article, available under the CC BY-SA 4.0 licence.