CNMD

Name

chondromodulin

Type

protein-coding

Position

52,703,198–52,740,142 (−)

Aliases

BRICD3, CHM-I, CHM1, LECT1, MYETS1

Ensembl

ENSG00000136110

RefSeq RNA

NM_001011705.2, NM_007015.3, XM_011534897.3, XM_011534898.3, XM_011534899.3

RefSeq protein

NP_001011705.1, NP_008946.1, XP_011533199.1, XP_011533200.1, XP_011533201.1

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

chondromodulin

Symbol

CNMD

Biotype

Protein coding

Organism

Homo sapiens

Location

13:52,703,198-52,740,142

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

via Wikidata · CC0