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코스미드
Sign in to saveAlso known as cosmids
A cosmid is a type of hybrid plasmid that contains a Lambda phage cos sequence. Often used as cloning vectors in genetic engineering, cosmids can be used to build genomic libraries. They were first described by Collins and Hohn in 1978. Cosmids can contain 37 to 52 (normally 45) kb of DNA, limits based on the normal bacteriophage packaging size. They can replicate as plasmids if they have a suitable origin of replication (ori): for example SV40 ori in mammalian cells, ColE1 ori for double-stranded DNA replication, or f1 ori for single-stranded DNA replication in prokaryotes. They frequently al
Research
6,548 papers- Cosmid Library Construction and Functional Cloning.Methods in molecular biology (Clifton, N.J.) · 2019
- Cosmid sequencing.Methods in molecular biology (Clifton, N.J.) · 1993
- Use of cosmid-derived and chromosome-specific canine microsatellites.The Journal of heredity · 1999
- Two neglected but valuable genetic tools for Escherichia coli and other bacteria: In vivo cosmid packaging and inducible plasmid replication.Molecular microbiology · 2023
- Constructing chromosome- and region-specific cosmid maps of the human genome.Genome · 1989
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