COTL1
Sign in to saveAlso known as CLP, coactosin like F-actin binding protein 1
Coactosin-like protein (COTL1 or CLP) is a protein that in humans is encoded by the COTL1 gene.
Gene data
COTL1- Name
- coactosin like F-actin binding protein 1
- Type
- protein-coding
- Position
- 84,565,596–84,618,136 (−)
- Aliases
- CLP
- Ensembl
- ENSG00000103187
- RefSeq RNA
- NM_021149.5
- RefSeq protein
- NP_066972.1
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
via MyGene.info
Gene · Ensembl
coactosin like F-actin binding protein 1
- Symbol
- COTL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:84,565,596-84,618,136
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein COTL1 PDB 1t2l.png
Show 8 more facts
- HomoloGene ID
- 10898
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23406
- genomic start
- 84565596
- chromosome
- human chromosome 16
- genomic end
- 84618078
- cytogenetic location
- 16q24.1
- expressed in
- gallbladder
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- External links
- Further reading
Coactosin-like protein (COTL1 or CLP) is a protein that in humans is encoded by the COTL1 gene.
== Function ==
Excerpted from Wikipedia’s “COTL1” article, available under the CC BY-SA 4.0 licence.