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GeneQ17909117· pop 7· linked from 6 articles

CPA1

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Also known as CPA, carboxypeptidase A1

protein-coding gene in the species Homo sapiens

Gene data

CPA1

Name: carboxypeptidase A1
Type: protein-coding
Position: 130,380,339–130,388,114 (+)
Aliases: CPA
Ensembl: ENSG00000091704
RefSeq RNA: NM_001868.4
RefSeq protein: NP_001859.1

This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015].

Gene Ontology

Biological process

proteolysis proteolysis proteolysis leukotriene metabolic process protein catabolic process response to cadmium ion

Molecular function

metallocarboxypeptidase activity metallocarboxypeptidase activity metallocarboxypeptidase activity metallocarboxypeptidase activity metallocarboxypeptidase activity protein binding exopeptidase activity zinc ion binding

Cellular component

extracellular region extracellular region extracellular region extracellular region

Pathways

Pancreatic secretion - Homo sapiens (human)Protein digestion and absorption - Homo sapiens (human)Developmental Biology Developmental Cell Lineages Developmental Cell Lineages of the Exocrine Pancreas Developmental Lineage of Pancreatic Acinar Cells

via MyGene.info

Gene · Ensembl

carboxypeptidase A1

Symbol: CPA1
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:130,380,339-130,388,114
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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