CPSF4

Name

cleavage and polyadenylation specific factor 4

Type

protein-coding

Position

99,438,908–99,458,910 (+)

Aliases

CPSF30, NAR, NEB-1, NEB1

Ensembl

ENSG00000160917

RefSeq RNA

NM_001081559.3, NM_001318160.2, NM_001318161.2, NM_001318162.2, NM_006693.4

RefSeq protein

NP_001075028.1, NP_001305089.1, NP_001305090.1, NP_001305091.1, NP_006684.1

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

cleavage and polyadenylation specific factor 4

Symbol

CPSF4

Biotype

Protein coding

Organism

Homo sapiens

Location

7:99,438,908-99,458,910

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

CRYO-EM STRUCTURE OF the human MPSF - Cleavage and polyadenylation specificity factor subunit 4 (2) 8E3Q.png

via Wikidata · CC0