CXXC1

Also known as 2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.

Gene data

CXXC1

Name: CXXC finger protein 1
Type: protein-coding
Position: 50,282,331–50,287,862 (−)
Aliases: 2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1, hCGBP
Ensembl: ENSG00000154832
RefSeq RNA: NM_001101654.2, NM_014593.4, XM_011525940.3, XM_017025718.3, XM_054318552.1
RefSeq protein: NP_001095124.1, NP_055408.2, XP_011524242.1, XP_016881207.1, XP_054174527.1

This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015].

Gene Ontology

Biological process

chromatin organization regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of DNA-templated transcription

Molecular function

cis-regulatory region sequence-specific DNA binding DNA binding protein binding zinc ion binding unmethylated CpG binding unmethylated CpG binding histone H3K4me3 reader activity

Cellular component

nucleus nucleus nucleus nucleoplasm nucleoplasm nuclear matrix nuclear speck nuclear speck

Pathways

Epigenetic regulation of gene expression Cellular responses to stress XBP1(S) activates chaperone genes IRE1alpha activates chaperones Unfolded Protein Response (UPR)Gene expression (Transcription)Cellular responses to stimuli Formation of WDR5-containing histone-modifying complexes Epigenetic regulation by WDR5-containing histone modifying complexes Male infertility

via MyGene.info

Gene · Ensembl

CXXC finger protein 1

Symbol: CXXC1
Biotype: Protein coding
Organism: Homo sapiens
Location: 18:50,282,331-50,287,862
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

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HomoloGene ID: 32221
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/30827
genomic start: 47808713
chromosome: human chromosome 18
genomic end: 50287839
cytogenetic location: 18q21.1

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Encyclopedic overview

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Contents

See also
References
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Further reading

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.

Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression.

Excerpted from Wikipedia’s “CXXC1” article, available under the CC BY-SA 4.0 licence.

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