CYTH4

Name

cytohesin 4

Type

protein-coding

Position

37,282,027–37,315,346 (+)

Aliases

CYT4, DJ63G5.1, PSCD4, cytohesin-4

Ensembl

ENSG00000100055

RefSeq RNA

NM_001318024.2, NM_013385.5

RefSeq protein

NP_001304953.1, NP_037517.1

This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015].

via MyGene.info

Gene · Ensembl

cytohesin 4

Symbol

CYTH4

Biotype

Protein coding

Organism

Homo sapiens

Location

22:37,282,027-37,315,346

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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