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thumb | right | alt=Flakes of dead skin cells | Flakes of dead skin cells Dander is material shed from the body of humans and other animals that have fur, hair, or feathers. The term is similar to dandruff, when an excess of flakes becomes visible. Skin flakes that come off the main body of an animal are dander, while the flakes of skin called dandruff come from the scalp and are composed of epithelial skin cells. The surface layer of mammalian skin is called the stratum corneum, which is shed as part of normal skin replacement.