DAZL

Name

deleted in azoospermia like

Type

protein-coding

Position

16,586,790–16,670,306 (−)

Aliases

DAZH, DAZL1, DAZLA, SPGYLA

Ensembl

ENSG00000092345

RefSeq RNA

NM_001190811.2, NM_001351.4

RefSeq protein

NP_001177740.1, NP_001342.2

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

via MyGene.info

Gene · Ensembl

deleted in azoospermia like

Symbol

DAZL

Biotype

Protein coding

Organism

Homo sapiens

Location

3:16,586,790-16,670,306

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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