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GeneQ18045668· pop 5· linked from 13 articles

Also known as A-SCID, DCLREC1C, RS-SCID, SCIDA, SNM1C, DNA cross-link repair 1C

protein-coding gene in the species Homo sapiens

Gene data

DCLRE1C
Name
DNA cross-link repair 1C
Type
protein-coding
Position
14,897,359–14,954,432 (−)
Aliases
A-SCID, DCLREC1C, RS-SCID, SCIDA, SNM1C
RefSeq RNA
NM_001033855.3, NM_001033857.3, NM_001033858.3, NM_001289076.2, NM_001289077.2
RefSeq protein
NP_001029027.1, NP_001029029.1, NP_001029030.1, NP_001276005.1, NP_001276006.1

This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

via MyGene.info

Gene · Ensembl

DNA cross-link repair 1C

Symbol
DCLRE1C
Biotype
Protein coding
Organism
Homo sapiens
Location
10:14,897,359-14,954,432
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

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