DDX3Y
Sign in to saveAlso known as DBY, DEAD-box helicase 3, Y-linked, DEAD-box helicase 3 Y-linked
ATP-dependent RNA helicase DDX3Y is an enzyme that in humans is encoded by the DDX3Y gene.
Gene data
DDX3Y- Name
- DEAD-box helicase 3 Y-linked
- Type
- protein-coding
- Chromosome
- Y
- Aliases
- DBY
The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
via MyGene.info
Gene · Ensembl
DEAD-box helicase 3 Y-linked
- Symbol
- DDX3Y
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr Y:12,904,108-12,920,478
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 55839
- exact match
- identifiers.org/ncbigene/8653
- genomic end
- 15032390
- genomic start
- 15016019
- cytogenetic location
- Yq11.221
Sources (4)
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
ATP-dependent RNA helicase DDX3Y is an enzyme that in humans is encoded by the DDX3Y gene.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome (DDX3X). The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Alternative splicing of this gene generates 2 transcripts, which differ only in the length of the 3' UTR.