DGCR2

Also known as DGS-C, IDD, LAN, SEZ-12, 9930034O06Rik, Dgsc, Sez12, mKIAA0163

The DGCR2 gene encodes the protein integral membrane protein DGCR2/IDD in humans.

In the Vinony graph

Vinony's link graph records 5 inbound references to DGCR2, and connects out to DiGeorge syndrome, Q180686 and human chromosome 22.

It is catalogued under the topic Genes on human chromosome 22.

Vinony links it to 7 Wikipedia language editions.

Gene data

DGCR2

Name: DiGeorge syndrome critical region gene 2
Type: protein-coding
Aliases: DGS-C, IDD, LAN, SEZ-12

Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

via MyGene.info

Gene · Ensembl

DiGeorge syndrome critical region gene 2

Symbol: DGCR2
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:19,036,280-19,122,461
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 31292
exact match: identifiers.org/ncbigene/9993
genomic end: 19109967
genomic start: 19023795
cytogenetic location: 22q11.21

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

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References
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The DGCR2 gene encodes the protein integral membrane protein DGCR2/IDD in humans.

Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. DGCR2 is thought to interact with the Reelin complex to regulate corticogenesis.

Excerpted from Wikipedia’s “DGCR2” article, available under the CC BY-SA 4.0 licence.