DGCR6

Also known as DiGeorge syndrome critical region gene 6

Protein DGCR6 is a protein that in humans is encoded by the DGCR6 gene.

In the Vinony graph

Within Vinony's link graph, DGCR6 is referenced by 2 other articles, and connects out to Q180686, DiGeorge syndrome and human chromosome 22.

It is catalogued under the topic Genes on human chromosome 22.

Its subject is documented across 6 Wikipedia language editions.

Gene data

DGCR6

Name: DiGeorge syndrome critical region gene 6
Type: protein-coding
Position: 18,905,677–18,916,623 (+)
Ensembl: ENSG00000183628
RefSeq RNA: NM_001368242.2, NM_005675.6, XM_047441509.1, XM_047441510.1, XM_054325952.1
RefSeq protein: NP_001355171.1, NP_005666.2, XP_047297465.1, XP_047297466.1, XP_054181927.1

DiGeorge syndrome, and more widely, the CATCH 22 syndrome, are associated with microdeletions in chromosomal region 22q11.2. The product of this gene shares homology with the Drosophila melanogaster gonadal protein, which participates in gonadal and germ cell development, and with the gamma-1 subunit of human laminin. This gene is a candidate for involvement in DiGeorge syndrome pathology and in schizophrenia. [provided by RefSeq, Nov 2008].

Gene Ontology

Biological process

cell adhesion animal organ morphogenesis

Molecular function

protein binding

Cellular component

nucleus extracellular matrix

via MyGene.info

Gene · Ensembl

DiGeorge syndrome critical region gene 6

Symbol: DGCR6
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:18,905,677-18,916,623
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 136000
exact match: identifiers.org/ncbigene/8214
cytogenetic location: 22q11.21|22q11
genomic end: 18901751
genomic start: 18893541

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Protein DGCR6 is a protein that in humans is encoded by the DGCR6 gene.

DiGeorge syndrome, and more widely, the CATCH 22 syndrome, are associated with microdeletions in chromosomal region 22q11.2. This gene product shares homology with the Drosophila melanogaster gonadal protein, which participates in gonadal and germ cell development, and with the human laminin gamma-1 chain, which upon polymerization with alpha- and beta-chains forms the laminin molecule. Laminin binds to cells through interaction with a receptor and has functions in cell attachment, migration, and tissue organization during development. This gene could be a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome.

Excerpted from Wikipedia’s “DGCR6” article, available under the CC BY-SA 4.0 licence.