DIS3L2
Sign in to saveAlso known as FAM6A, PRLMNS, hDIS3L2, DIS3 like 3'-5' exoribonuclease 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2 is a protein in humans that is encoded by the DIS3L2 gene. The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012].
Gene data
DIS3L2- Name
- DIS3 like 3'-5' exoribonuclease 2
- Type
- protein-coding
- Position
- 231,961,245–232,344,350 (+)
- Aliases
- FAM6A, PRLMNS, hDIS3L2
- Ensembl
- ENSG00000144535
- RefSeq RNA
- NM_001257281.2, NM_001257282.2, NM_152383.5, NR_046476.2, NR_046477.2
- RefSeq protein
- NP_001244210.1, NP_001244211.1, NP_689596.4
The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
DIS3 like 3'-5' exoribonuclease 2
- Symbol
- DIS3L2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:231,961,245-232,344,350
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 62417
- genomic end
- 233209060
- exact match
- identifiers.org/ncbigene/129563
- genomic start
- 232825955
- cytogenetic location
- 2q37.1
- Commons category
- DIS3L2
Sources (7)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Clinical significance
- References
- Further reading
DIS3 mitotic control homolog (S. cerevisiae)-like 2 is a protein in humans that is encoded by the DIS3L2 gene. The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012].
== Clinical significance == Mutations in DIS3L2 cause Perlman syndrome.