DPAGT1
Sign in to saveAlso known as ALG7, CDG-Ij, CDG1J, CMSTA2, D11S366, DGPT, DPAGT, DPAGT2
UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase is an enzyme that in humans is encoded by the DPAGT1 gene.
Gene data
DPAGT1- Name
- dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
- Type
- protein-coding
- Position
- 119,095,979–119,108,331 (−)
- Aliases
- ALG7, CDG-Ij, CDG1J, CMS13, CMSTA2, D11S366, DGPT, DPAGT, DPAGT2, G1PT
- Ensembl
- ENSG00000172269
- RefSeq RNA
- NM_001382.4, NM_203316.1, XM_005271422.4, XM_011542648.3, XM_017017294.3
- RefSeq protein
- NP_001373.2, XP_005271479.1, XP_011540950.1, XP_016872783.1, XP_016872784.1
The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
- Symbol
- DPAGT1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:119,095,979-119,108,331
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~5 min read
Encyclopedic overview
7 sectionsContents
- Chemistry
- Structure
- Biochemistry
- DPAGT1 inhibitors
- References
- Further reading
- External links
UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase is an enzyme that in humans is encoded by the DPAGT1 gene.
Mutations in DPAGT1 cause myasthenia.
Excerpted from Wikipedia’s “DPAGT1” article, available under the CC BY-SA 4.0 licence.