DPM2

Name

dolichyl-phosphate mannosyltransferase subunit 2, regulatory

Type

protein-coding

Position

127,935,090–127,937,879 (−)

Aliases

CDG1U

Ensembl

ENSG00000136908

RefSeq RNA

NM_001378436.1, NM_001378437.1, NM_003863.4, NM_152690.1, NR_165631.1

RefSeq protein

NP_001365365.1, NP_001365366.1, NP_003854.1

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

dolichyl-phosphate mannosyltransferase subunit 2, regulatory

Symbol

DPM2

Biotype

Protein coding

Organism

Homo sapiens

Location

9:127,935,090-127,937,879

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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