Also known as TRAMP, dermatopontin
Dermatopontin also known as tyrosine-rich acidic matrix protein (TRAMP) is a protein that in humans is encoded by the DPT gene. Dermatopontin is a 22-kDa protein of the noncollagenous extracellular matrix (ECM) estimated to comprise 12 mg/kg of wet dermis weight. To date, homologues have been identified in five different mammals and 12 different invertebrates with multiple functions. In vertebrates, the primary function of dermatopontin is a structural component of the ECM (interaction with decorin and modification of collagen fibrillogenesis), cell adhesion, modulation of TGF-β activity
Gene data
DPT- Name
- dermatopontin
- Type
- protein-coding
- Position
- 168,695,246–168,729,207 (−)
- Aliases
- TRAMP
- Ensembl
- ENSG00000143196
- RefSeq RNA
- NM_001937.5
- RefSeq protein
- NP_001928.2
Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
dermatopontin
- Symbol
- DPT
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:168,695,246-168,729,207
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 1458
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1805
- genomic end
- 168729206
- genomic start
- 168695468
- chromosome
- human chromosome 1
- cytogenetic location
- 1q24.2
- expressed in
- fundus
Sources (4)
via Wikidata · CC0
~8 min read
Encyclopedic overview
6 sectionsContents
- Cellular and tissue distribution
- Function
- Cell adhesion
- Applications
- References
- Further reading
Dermatopontin also known as tyrosine-rich acidic matrix protein (TRAMP) is a protein that in humans is encoded by the DPT gene. Dermatopontin is a 22-kDa protein of the noncollagenous extracellular matrix (ECM) estimated to comprise 12 mg/kg of wet dermis weight. To date, homologues have been identified in five different mammals and 12 different invertebrates with multiple functions. In vertebrates, the primary function of dermatopontin is a structural component of the ECM (interaction with decorin and modification of collagen fibrillogenesis), cell adhesion, modulation of TGF-β activity and cellular quiescence). It also has pathological involvement in heart attacks (increased expression around myocardial infarct zone) and decreased expression in leiomyoma and fibrosis. In invertebrate, dermatopontin homologue plays a role in hemagglutination, cell-cell aggregation, and expression during parasite infection.
== Cellular and tissue distribution ==
Excerpted from Wikipedia’s “DPT” article, available under the CC BY-SA 4.0 licence.
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