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DRB may refer to: Defence Research and Development Canada, the Canadian Defence Research Board Deshastha Rigvedi Brahmins Deutsche Reichsbahn, the German Imperial Railways or its wartime locomotive classes such as the DRB Class 50 Deutscher Richterbund, the German Association of Judges 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole, a chemical compound that inhibits gene transcription Digital Radio Broadcast Specialist, a professional title regulated by the Society of Broadcast Engineers Douay–Rheims Bible DRB-HICOM, a Malaysian automotive company The Dublin Review of Books, a literary publication based in Ireland The IATA airport code for Derby Airport (Western Australia) in Western Australia