ECH1

Also known as HPXEL, enoyl-CoA hydratase 1, peroxisomal, enoyl-CoA hydratase 1

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an enzyme that in humans is encoded by the ECH1 gene.

In the Vinony graph

Within Vinony's link graph, ECH1 is referenced by 2 other articles, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.

Vinony files it under Beta oxidation and Genes on human chromosome 19.

Its subject is documented across 5 Wikipedia language editions.

Gene data

ECH1

Name: enoyl-CoA hydratase 1
Type: protein-coding
Aliases: HPXEL

This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

enoyl-CoA hydratase 1

Symbol: ECH1
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:38,815,415-38,831,874
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: 2vre.png

Show 8 more facts

HomoloGene ID: 1069
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1891
chromosome: human chromosome 19
genomic start: 39306062
genomic end: 38831841
cytogenetic location: 19q13.2
Commons category: Dienoyl-CoA isomerase (delta3-delta2-enoyl-CoA isomerase)

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

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Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an enzyme that in humans is encoded by the ECH1 gene.

This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, Δ3,5-Δ2,4-dienoyl-CoA isomerase, contains a C-terminal peroxisomal targeting sequence and localizes to peroxisomes. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.

Excerpted from Wikipedia’s “ECH1” article, available under the CC BY-SA 4.0 licence.